Laboratoire de Physique Théorique et Modèles Statistiques

Séminaire du LPTMS : Gunnar Boldhaus

Knockouts, Robustness and Cell Cycles

Gunnar Boldhaus (Bioinformatics, University of Leipzig, Germany)

The response to a knockout of a node is a characteristic feature of a networked dynamical system. Knockout resilience in the dynamics of the remaining nodes is a sign of robustness. Here we study the effect of knockouts for binary state sequences and their implementations in terms of Boolean threshold networks. Beside random sequences with biologically plausible constraints, we analyze the cell cycle sequence of the species Saccharomyces cerevisiae and the Boolean networks implementing it. Comparing with an appropriate null model we do not
find evidence that the yeast wildtype network is optimized for High knockout resilience. Our notion of knockout resilience weakly correlates with the size of the basin of attraction, which has also been considered a measure of robustness.

Jeudi 24 juin à 16h

LPTMS-batiment 100, salle 201, Orsay


Calendrier des séminaires

Mai
Juillet
Juin 2010
lun. mar. mer. jeu. ven.
 
1
16:00» Seminaire LPTMS: Uzy Smilansky (Weizmann)
2
3
14:00» Séminaire commun LPT-LPTMS : Petr Sulc
4
11:00» Séminaire du LPTMS : Yoshiyuki Kabashima
7
14:00» Séminaire PHYSTAT-SUD : Jon Keating
8
11:00» Seminaire LPTMS : Luigi Cantini (LPT ENS)
9
10
11
14
15
11:00» Seminaire LPTMS: Rhoda Hawkins
16
17
18
14:00» Séminaire Physique Biologique et Systèmes Complexes : Guillaume Romet-Lemonne
21
22
11:00» Semianire LPTMS: Martin Lenz (Chicago)
23
24
16:00» Séminaire du LPTMS : Gunnar Boldhaus
25
10:30» Soutenance de thèse : Carlos Eduardo Alvarez Cabrera
15:00» Séminaire exceptionnel du LPTMS : Paolo Solinas
28
29
11:00» Seminaire LPTMS: Celine Nadal, Alvaro Rojo
30