Physics-Biology interface seminar

Held every second Wednesday at 11am in the joint seminar room of LPTMS and FAST in Orsay, this seminar series aims to be a central forum for the Physics/Biology interface in the south of Paris.

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Other seminars and conferences you might be interested in:

Paris-Saclay Biomechanics seminar - last Thu. of the month in Palaiseau (subscribe to their announcements)
Seminar of the Physical Chemistry Laboratory - in Orsay

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Prion-like propagation of alpha-synuclein assemblies in synucleinopathies, similarities with Tau in Tauopathies

Ronald Melki (Institut François Jacob, CEA & CNRS)

The aggregation of proteins within the central nervous system is deleterious and associated to neurodegenerative disorders. The aggregation of the proteins alpha-synuclein and Tau are associated to synucleinopathies, in particular Parkinson's disease, and tauopathies, among which Alzheimer’s disease, respectively. How alpha-synuclein and Tau aggregates, how those aggregates traffic between cells, amplify by recruiting endogenous monomeric alpha-synuclein or Tau and cause distinct synucleinopathies or tauopathies is unclear. I will explain the molecular events that lead to alpha-synuclein or Tau aggregation. I will show that alpha-synuclein and Tau aggregates bind to neurons cell membranes and explain the cellular consequences of binding. The similarities and differences between alpha-synuclein and Tau will be highlighted. I will explain how alpha-synuclein and Tau aggregates penetrate the cells and get transported. Finally, I will describe how the structure of the fibrillar polymorphs alpha-synuclein and Tau aggregation yield distinct diseases.

References:

  1. Brundin P et al. (2010) Nat Rev Mol Cell Biol. 11:301-7.
  2. Bousset L et al. (2013) Nat Commun. 4:2575.
  3. Peelaerts W et al. (2015) Nature 522:340-4.
  4. Shrivastava AN et al. (2015) EMBO J. 34:2408-23.
  5. Brahic M et al. (2016) Acta Neuropathol. 131:539-48.
  6. Makky A et al. (2016) Sci Rep. 6:37970.
  7. Flavin W et al. (2017) Acta Neuropathol. 134:629-653.
  8. Shrivastava AN et al. (2017) Neuron 95:33-50.
  9. Melki R (2018) Neurobiol Dis. 109:201-208.
  10. Gribaudo S et al. (2019) Stem Cell Reports. 12:230-244.
  11. Shrivastava AN et al. (2019) EMBO J. 38. pii: e99871.
  12. Fenyi A et al., (2019) Neurobiol Dis 129:38-43.
Location: Salle des séminaires du FAST et du LPTMS, bâtiment Pascal n°530

Stéphane Vassilopoulos (Sorbonne Université)

Location: Salle des séminaires du FAST et du LPTMS, bâtiment Pascal n°530


Anne-Virginie Salsac (Université de Technologie de Compiègne)

Location: Salle des séminaires du FAST et du LPTMS, bâtiment Pascal n°530

Davy Martin (INRA Jouy-en-Josas)

Location: Salle des séminaires du FAST et du LPTMS, bâtiment Pascal n°530