Cross-talk in host–parasite associations: What do past and recent proteomics approaches tell us?

Chérif Chetouhi 1 Johan Panek 2 Ludovic Bonhomme 3 Hicham ElalaouiCatherine Texier 4 Thierry Langin 1 Charissa De BekkerSerge Urbach 5, 6, 7 Edith Demettre 6 Dorothée Missé 8 Philippe Holzmuller 9 David P. HughesAndreas Zanzoni 10 Christine Brun 11, 10 David G. Biron 12

Infection, Genetics and Evolution, 2015, 33, pp.84 – 94. <10.1016/j.meegid.2015.04.015>

A cross-talk in host-parasite associations begins when a host encounters a parasite. For many host-parasite relationships, this cross-talk has been taking place for hundreds of millions of years. The co-evolution of hosts and parasites, the familiar ‘arms race’ results in fascinating adaptations. Over the years, host-parasite interactions have been studied extensively from both the host and parasitic point of view. Proteomics studies have led to new insights into host-parasite cross-talk and suggest that the molecular strategies used by parasites attacking animals and plants share many similarities. Likewise, animals and plants use several common molecular tactics to counter parasite attacks. Based on proteomics surveys undertaken since the post-genomic era, a synthesis is presented on the molecular strategies used by intra- and extracellular parasites to invade and create the needed habitat for growth inside the host, as well as strategies used by hosts to counter these parasite attacks. Pitfalls in deciphering host-parasite cross-talk are also discussed. To conclude, helpful advice is given with regard to new directions that are needed to discover the generic and specific molecular strategies used by the host against parasite invasion as well as by the parasite to invade, survive, and grow inside their hosts, and to finally discover parasitic molecular signatures associated with their development.

  • 1. GDEC – Génétique Diversité et Ecophysiologie des Céréales
  • 2. ASCR – Czech Academy of Sciences [Prague]
  • 3. SMiLES – Spectroscopie, Modélisation, Interfaces pour L’Environnement et la Santé
  • 4. LPTMS – Laboratoire de Physique Théorique et Modèles Statistiques
  • 5. Faculty of Sciences, University of Montpellier, Montpellier, France
  • 6. IGF – Institut de Génomique Fonctionnelle
  • 7. Functional Proteomics Platform, Institute of Functional Genomics, Montpellier, France
  • 8. MIVEGEC – Laboratoire de Parasitologie-Mycologie, Montpellier
  • 9. CMAEE – Contrôle des maladies animales exotiques et émergentes [Montpellier]
  • 10. TAGC – Technologies avancées pour le génôme et la clinique
  • 11. CNRS – Centre National de la Recherche Scientifique
  • 12. UMR 6023
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