Physics-Biology interface seminar

Held every second Wednesday at 11am in the moyen amphi at LPS (not LPTMS!) in Orsay, this seminar series aims to be a central forum for the Physics/Biology interface in the south of Paris.

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Other seminars and conferences you might be interested in:

Paris-Saclay Biomechanics seminar - last Thu. of the month in Palaiseau (subscribe to their announcements)
Seminar of the Physical Chemistry Laboratory - in Orsay

Informations for speakers
Past seminars
Contact the organizer


Adaptive division control in stressed bacterial cells

Shiladitya Banerjee (UCL, UK)

Control of cell size is a fundamental adaptive trait that underlies the coupling between cell growth and division. Cells possess the unique ability to adapt their size and shapes in response to environmental cues, thereby translating extracellular information into decisions to grow or divide. However, the physical mechanisms mediating the regulation of cell size and division timing remain poorly understood. In this talk, I will discuss our recent discovery of an adaptive model of cell size control in bacteria, where the decision to divide is tightly regulated by the spatial patterning of cell wall growth modes. Using a combination of stochastic mechanical modelling and single-cell experiments, I will elucidate the implications of the size control model for cellular fitness adaptation under stress. In particular, our results show that morphological transformations provide fitness and survival advantages to bacteria under sustained antibiotic treatment.

Location: Moyen Amphi, Building 510, Université Paris-Sud Orsay

Pere Roca-Cusachs (Institute for Bioengineering of Catalonia, Universitat de Barcelona, Spain)

Location: Amphi BLANDIN du LPS de la Faculté des Sciences d’Orsay (Bâtiment 510)

Mechano-sensitive adhesion in cell spreading and crawling

Pierre Sens (Institut Curie, Paris)

Crawling cell motility is powered by actin polymerization and acto-myosin contraction. When moving over a flat and rigid substrate, cells usually develop thin and broad protrusions at their front, called lamellipodia, where actin polymerisation generates a protrusive force pushing the front edge of the cell forward. The lamellipodium displays interesting dynamics, including normal and lateral waves, possibly relevant to cell polarisation and the initiation of motion. I will discuss a stochastic model of mechano-sensitive cell adhesion, and discuss its relevance for symmetry breaking, cell polarisation, and motility. I will then discuss a generic model of micro-crawlers, built as an extension of low Reynolds number micro-swimmers, that highlights the crucial role of mechano-sensitive adhesion for the active crawling of cells and biomimetic objects.

Location: Moyen Amphi, Building 510, Université Paris-Sud Orsay

Pierre Recho (LIPHY, Grenoble)

Location: Moyen Amphi, Building 510, Université Paris-Sud Orsay

Emmanuel de Langre (École polytechnique, Palaiseau, France)

Location: Moyen Amphi, Building 510, Université Paris-Sud Orsay

David Bensimon (LPS-ENS, Paris, France)

Location: Moyen Amphi, Building 510, Université Paris-Sud Orsay