10th August 2017 : Institut Curie-NCBS Joint Postdoctoc

*_Institut Curie-NCBS _**_Joint _**_Postdoctoral Fellowship Program_*

*About Us*

This is a joint project between theorists (Prof. Madan Rao
and Prof. Pierre Sens
)
and experimentalists (Prof. Patricia Bassereau

and Dr. Shashi Thutupalli ) at two
institutes (National Centre for Biological Sciences
, Bangalore, India and the Institut Curie
, Paris, France) as part of a joint
postdoctoral fellowship program. The aim is to understand the
organization and emergence of structure and function of the Golgi
apparatus, a complex membrane bound organelle within cells.

*The position*
**
We are seeking highly motivated, outstanding candidates for 2
postdoctoral positions to investigate the biophysics of the Golgi
apparatus in cells, both theoretically and experimentally.

We propose to use the principles of soft condensed matter and
non-equilibrium physics to understand the organization and emergence of
structure and function of the Golgi apparatus. We view this as a process
of self-emergent structure and function but also as a complex
information processing problem. The Golgi apparatus is comprised of a
stack of lipid bilayer compartments (cisternae), each with a unique
chemical identity and serves as a protein processing factory as proteins
and other macromolecules progress in a stepwise manner through the
stacks. The emergence of the form and function of such a biochemical
factory from simple soft matter components such as lipids and proteins
has remained a mystery for a long time. Resolving this mystery has
fundamental bearing not only for understanding trafficking within cells
but also for cellular self-organization in general. The sequential
chemical processing within the Golgi apparatus can be viewed as driven
nonequilibrium chemical reactions. We aim to build in vitro model lipid
membrane systems incorporating non-equilibrium processes, such as
membrane fusion, sorting and spontaneous scission using a combination of
microfluidics and soft matter techniques. Using these basic ingredients,
we will study the de novo emergence of structures resembling the Golgi.
Of particular emphasis will be the quantitative control of the
transport, fusion, fission and segregation of the structures
commensurate with in vitro studies. These experiments and corresponding
in vitro measurements will be reconciled with theory.

*Your profile*
**
An extensive background in soft matter physics or related subjects.

(i) For the experimentalists, we are looking for expertise in artificial
membrane systems, microfluidics, microscopy, optical manipulation and
related physical techniques. Persons with a theoretical background with
a strong interest in building experiments are also encouraged to apply.

(ii) For theorists, background in soft condensed matter, nonequilibrium
statistical mechanics and membrane biophysics will be highly relevant.

*Our offer*
**
The total duration of the fellowship is for a maximum duration of 4
years. This fellowship is a jointly appointment Postdoctoral Fellow
between the NCBS, India and the Institut Curie, France. The time of the
fellowship is to be divided between the partnering institutions. Right
from the start, the candidates will be encouraged and even expected to
develop a great degree of independence — from drafting the initial
details of the project within the broad framework outlined to proposing
interesting directions going forward.

*Your application*
**
Please send your application (CV, a list of publications and two
reference letters) by email to shashi@ncbs.res.in
, patricia.bassereau@curie.fr
, pierre.sens@curie.fr
, madan@ncbs.res.in
before 10th September 2017