Physics-Biology interface seminar: David Head

High-fidelity computational modelling of biofilms and fibre networks

David Head (University of Leeds, UK)

NOTE THE NEW LOCATION (due to renovation work at LPS)

Mathematical models of complex systems can help develop fundamental insight and accelerate the development of
novel materials and therapeutic treatments, but the simplifications that must necessarily be made reduce both
validity and predictability, even for complex models that are solved numerically. Here I will describe recent
results in two research streams aimed at developing and validating high-fidelity in silico models for biofilms
and fibre networks, aiming to reduce the realism gap to experimental systems while maintaining sufficient
performance to permit solution for times and system sizes of interest. The first is a bespoke model for biofilms
in which mechanical relaxation between cells replaces the « pushing » rules typically used, and has been applied
to the archetypal biofilm of dental plaque, revealing insight into long-term ecological dynamics not easily
assayed experimentally. Secondly, I will discuss dynamic simulations of peptide gels and collagen hydrogel
scaffolds, both having important applications as novel biomaterials but where network formation must also be
simulated to better approximate the experiments; reaching realistic time scales is a substantial challenge.


Date/Time : 30/11/2016 - 11:00 - 12:00

Location : LPTMS, salle 201, 2ème étage, Bât 100, Campus d'Orsay

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