Physics-Biology interface seminar: Olivier Rivoire

How history shapes geometry in a model of protein evolution

Olivier Rivoire (Laboratoire interdisciplinaire de Physique, UJF Grenoble)

The interactions between amino acids in a protein are heterogeneous but not arbitrary: they enable proteins to perform specific biochemical « functions ». Understanding these interactions may require, however, looking beyond current functional requirements, to the evolutionary history of proteins. I will illustrate this point with a simple statistical mechanics model, which I will motivate with observations and experiments on natural proteins. The model relates the parameters controlling the evolution of a protein to the organization of the interactions inside its structure.


Date/Time : 26/01/2015 - 11:00 - 12:00

Location : Moyen Amphi, Building 510, Université Paris-Sud Orsay

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